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J Antimicrob Chemother. 2010 Aug;65(8):1753-8. doi: 10.1093/jac/dkq183. Epub 2010 May 27.

Dose-ranging pharmacokinetics of colistin methanesulphonate (CMS) and colistin in rats following single intravenous CMS doses.

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1
INSERM ERI-23, 40 Avenue du Recteur Pineau, 86000 Poitiers, France.

Abstract

OBJECTIVES:

The aim of this study was to evaluate the effect of colistin methanesulphonate (CMS) dose on CMS and colistin pharmacokinetics in rats.

METHODS:

Three rats per group received an intravenous bolus of CMS at a dose of 5, 15, 30, 60 or 120 mg/kg. Arterial blood samples were drawn at 0, 5, 15, 30, 60, 90, 120, 150 and 180 min. CMS and colistin plasma concentrations were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The pharmacokinetic parameters of CMS and colistin were calculated by non-compartmental analysis.

RESULTS:

Linear relationships were observed between CMS and colistin AUCs to infinity and CMS doses, as well as between CMS and colistin C(max) and CMS doses.

CONCLUSIONS:

CMS and colistin pharmacokinetics were linear for a range of colistin concentrations covering the range of values encountered and recommended in patients even during treatment with higher doses.

PMID:
20507861
DOI:
10.1093/jac/dkq183
[Indexed for MEDLINE]

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