Format

Send to

Choose Destination
See comment in PubMed Commons below
BMC Res Notes. 2010 May 27;3:147. doi: 10.1186/1756-0500-3-147.

ParMap, an algorithm for the identification of small genomic insertions and deletions in nextgen sequencing data.

Author information

  • 1Department of Biomedical Informatics, Columbia University College of Physicians and Surgeons, New York, NY, USA. hossein@c2b2.columbia.edu.

Abstract

BACKGROUND:

Next-generation sequencing produces high-throughput data, albeit with greater error and shorter reads than traditional Sanger sequencing methods. This complicates the detection of genomic variations, especially, small insertions and deletions.

FINDINGS:

Here we describe ParMap, a statistical algorithm for the identification of complex genetic variants, such as small insertion and deletions, using partially mapped reads in nextgen sequencing data.

CONCLUSIONS:

We report ParMap's successful application to the mutation analysis of chromosome X exome-captured leukemia DNA samples.

PMID:
20507604
PMCID:
PMC2897800
DOI:
10.1186/1756-0500-3-147
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center