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Arch Physiol Biochem. 2010 Oct-Dec;116(4-5):158-62. doi: 10.3109/13813455.2010.485206. Epub 2010 May 28.

The Lucid Proteomics System for top-down biomarker research.

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Bio-Rad Laboratories, Division Bio-Recherche, 3, Boulevard Raymond Poincaré, Marnes la Coquette 92430, France.


Advances have been made in recent years for both "top-down" and "bottom-up" profiling approaches to biomarker discovery. Top-down protein profiling via SELDI-TOF mass spectrometry has been used by researchers in many fields of study to discover native protein biomarker candidates from a variety of sample types, but has been limited without a means for straightforward identification of these candidates. Bio-Rad has recently partnered with Bruker Daltonics to create the Lucid Proteomics System, a complete SELDI-based research workflow--system qualification, biomarker discovery, data analysis, and biomarker purification/identification--using Bruker's flex series of TOF and TOF/TOF mass spectrometers, which have long provided consistent performance and high value data for MALDI applications. This collaboration enables both top-down and bottom-up proteomics approaches on a single high performance MALDI-TOF MS platform for maximum coverage of the proteome--allowing greater flexibility with experimental design and accelerating biomarker research programmes.

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