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Alzheimer Dis Assoc Disord. 2010 Apr-Jun;24(2):182-9. doi: 10.1097/WAD.0b013e3181c727f7.

Complexity analysis of spontaneous brain activity in Alzheimer disease and mild cognitive impairment: an MEG study.

Author information

1
Centro de Magnetoencefalografía Dr. Pérez-Modrego, Facultad de Medicina, Pabellón, Universidad Complutense de Madrid, Madrid, Spain. aferlucas@med.ucm.es

Abstract

Nonlinear analyses have shown that Alzheimer disease (AD) patients' brain activity is characterized by a reduced complexity and connectivity. The aim of this study is to define complexity patterns of mild cognitive impairment (MCI) patients. Whole-head magnetoencephalography recordings were obtained from 18 diagnosed AD patients, 18 MCI patients, and 18 healthy controls during resting conditions. Lempel-Ziv complexity (LZC) values were calculated. MCI patients exhibited intermediary LZC scores between AD patients and controls. A combination of age and posterior LZC scores allowed ADs-MCIs discrimination with 94.4% sensitivity and specificity, whereas no LZC score allowed MCIs---controls discrimination. AD patients and controls showed a parallel tendency to diminished LZC scores as a function of age, but MCI patients did not exhibit such "normal" tendency. Accordingly, anterior LZC scores allowed MCIs-controls discrimination for subjects below 75 years. MCIs exhibited a qualitatively distinct relationship between aging and complexity reduction, with scores higher than controls in older individuals. This fact might be considered a new example of compensatory mechanism in MCI before fully established dementia.

PMID:
20505435
DOI:
10.1097/WAD.0b013e3181c727f7
[Indexed for MEDLINE]

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