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Int Immunol. 2010 Aug;22(8):619-25. doi: 10.1093/intimm/dxq053. Epub 2010 May 26.

Early events governing memory CD8+ T-cell differentiation.

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1
Center for Integrated Immunology and Vaccine Research, Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-1319, USA.

Abstract

Understanding the regulation of the CD8(+) T-cell response and how protective memory cells are generated has been intensely studied. It is now appreciated that a naive CD8(+) T cell requires at least three signals to mount an effective immune response: (i) TCR triggering, (ii) co-stimulation and (iii) inflammatory cytokines. Only recently have we begun to understand the molecular integration of those signals and how early events regulate the fate decisions of the responding CD8(+) T cells. This review will discuss the recent findings about both the extracellular and intracellular factors that regulate the destiny of responding CD8(+) T cells.

PMID:
20504887
PMCID:
PMC2908475
DOI:
10.1093/intimm/dxq053
[Indexed for MEDLINE]
Free PMC Article
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