(1)H NMR Study of the solution structure of sarafotoxin-S6b

A Aumelas; L Chiche; E Mahe; D Le-Nguyen; P Sizun; P Berthault; B Perly

doi:10.1016/0197-0186(91)90141-y

(1)H NMR Study of the solution structure of sarafotoxin-S6b

Neurochem Int. 1991;18(4):471-5. doi: 10.1016/0197-0186(91)90141-y.

Authors

A Aumelas¹, L Chiche, E Mahe, D Le-Nguyen, P Sizun, P Berthault, B Perly

Affiliation

¹ Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France.

PMID: 20504727
DOI: 10.1016/0197-0186(91)90141-y

Abstract

Sarafotoxin-S6b has been synthesized and studied by (1)H NMR in 50 50 acetonitrile/water mixture. All spin systems were identified and assigned with the aid of 2D experiments. On the basis of these data, a 3D structure of sarafotoxin is proposed and compared to that of [Nle(7)]endothelin obtained in the same conditions. From this study, it appeared that sarafotoxin-S6b and [Nle(7)]endothelin roughly share the same 3D structure, the main differences being located in the 4-7 loop bearing the sequence variation.