Format

Send to

Choose Destination
Eur J Clin Nutr. 2010 Aug;64(8):792-9. doi: 10.1038/ejcn.2010.75. Epub 2010 May 26.

Serum fatty acids and risk of advanced beta-cell autoimmunity: a nested case-control study among children with HLA-conferred susceptibility to type I diabetes.

Author information

1
Nutrition Unit, National Institute for Health and Welfare, Helsinki, Finland. suvi.virtanen@thl.fi

Abstract

BACKGROUND/OBJECTIVES:

N-3 (omega-3) fatty acids have been reported to decrease the risk for development of beta-cell autoimmunity and clinical type I diabetes. We set out to examine whether different serum fatty acids are associated with the development of advanced beta-cell autoimmunity in children carrying human leukocyte antigen DQ beta-1 (HLA-DQB1)-conferred susceptibility to type I diabetes.

SUBJECTS/METHODS:

Within a cohort, serum total fatty acid composition of 108 children with advanced beta-cell autoimmunity and of 216 matched persistently autoantibody-negative controls was analyzed using gas chromatography. Non-fasting serum samples were obtained annually at the ages of 1-6 years. Conditional logistic regression was applied to analyze the associations between advanced beta-cell autoimmunity and serum fatty acids.

RESULTS:

The serum fatty acid profile of myristic acid (odds ratio (OR) 1.48, 95% confidence interval (CI) 1.09-2.00, P=0.011), pentadecanoic acid (OR 1.65, 95% CI 1.19-2.28, P=0.003), palmitoleic acid isomers 16:1 n-7 (omega-7) (OR 1.41, 95% CI 1.03-1.92, P=0.030) and 16:1 n-9 (omega-9) (OR 1.45, 95% CI 1.05-2.01, P=0.026) and conjugated linoleic acid (OR 1.67, 95% CI 1.16-2.41, P=0.006) closest to the time of the appearance of multiple autoantibodies were positively associated with the risk of advanced beta-cell autoimmunity after adjustment for potential confounding factors. Serum linoleic acid showed inverse, marginal association with the end point.

CONCLUSIONS:

Serum biomarkers of milk and ruminant meat fat consumption are directly associated and linoleic acid is inversely associated with advanced beta-cell autoimmunity in children with HLA-conferred susceptibility to type I diabetes.

PMID:
20502469
DOI:
10.1038/ejcn.2010.75
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center