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Arch Dis Child. 2010 Jun;95(6):478-81. doi: 10.1136/adc.2009.169375.

Long-term safety and effectiveness of lopinavir/ritonavir in antiretroviral-experienced HIV-1-infected children.

Author information

1
Division of Infectious Diseases, University Children's Hospital, Basel, Switzerland. christoph.rudin@unibas.ch

Abstract

AIM:

To evaluate the long-term safety and effectiveness of lopinavir/ritonavir (LPV/r) in a population-based cohort of HIV-1-infected children.

METHODS:

All children enrolled in the Swiss Mother and Child HIV Cohort Study, treated with LPV/r-based combination antiretroviral treatment (cART) between November 2000 and October 2008, were included.

RESULTS:

88 children (25 (28%) protease inhibitor (PI)-naive, 16 (18%) ART-naive) were analysed (251 patient-years on LPV/r). After 48 weeks on LPV/r, 70 children had a median (interquartile range (IQR)) decrease in HIV-1 viral load of 4.25 log (5.45-3.17; PI-naive, n=17) and 2.53 (3.68-1.38; PI-experienced, n=53). Median (IQR) increase in CD4 count was 429 (203-593; PI-naive) and 177 (21-331; PI-experienced) cells/microl. These effects remained stable throughout 192 weeks for 25 children. Treatment was stopped for viral rebound in seven and suspected toxicity in 12 children.

CONCLUSION:

Long-term treatment with LPV/r-based cART is safe and effective in HIV-1-infected children.

PMID:
20501542
DOI:
10.1136/adc.2009.169375
[Indexed for MEDLINE]
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