Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur Heart J. 2010 Jul;31(14):1730-6. doi: 10.1093/eurheartj/ehq146. Epub 2010 May 25.

A multimarker approach to assess the influence of inflammation on the incidence of atrial fibrillation in women.

Author information

1
Center for Arrhythmia Prevention Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. conend@uhbs.ch

Abstract

AIMS:

To assess the joint influence of inflammatory biomarkers on the risk of incident atrial fibrillation (AF) in women.

METHODS AND RESULTS:

We performed a prospective cohort study among women participating in the Women's Health Study. All women were free of AF at study entry and provided a baseline blood sample assayed for high-sensitivity C-reactive protein, soluble intercellular adhesion molecule-1, and fibrinogen. To evaluate the joint effect of these three biomarkers, an inflammation score was created that ranged from 0 to 3 and reflected the number of biomarkers in the highest tertile per individual. During a median follow-up of 14.4 years, 747 of 24,734 women (3.0%) experienced a first AF event. Assessed individually, all three biomarkers were associated with incident AF, even after adjustment for traditional risk factors. When combined into an inflammation score, a strong and independent relationship between inflammation and incident AF emerged. Across increasing inflammation score categories, there were 1.66, 2.22, 2.73, and 3.25 AF events per 1000 person-years of follow-up. The corresponding hazard ratios (95% confidence intervals) across inflammation score categories were 1.0, 1.22 (1.00-1.49), 1.32 (1.06-1.65), and 1.59 (1.22-2.06) (P for linear trend 0.0006) after multivariable adjustment.

CONCLUSION:

In this large-scale prospective study among women without a history of cardiovascular disease, markers of systemic inflammation were significantly related to AF even after controlling for traditional risk factors.

PMID:
20501475
PMCID:
PMC2903714
DOI:
10.1093/eurheartj/ehq146
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems Icon for PubMed Central
    Loading ...
    Support Center