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J Infect Dis. 2010 Jul 1;202(1):93-103. doi: 10.1086/653083.

Molecular epidemiology and brief history of emerging adenovirus 14-associated respiratory disease in the United States.

Author information

1
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA. akajon@lrri.org

Abstract

BACKGROUND:

First isolated in the Netherlands in 1955 during an outbreak of acute respiratory disease (ARD) among military recruits, human adenovirus 14 (HAdV-14) has historically been considered rare. With no precedent of circulation in North America, HAdV-14 has been isolated from military and civilian cases of ARD of variable severity since 2003 in the United States.

METHODS:

Ninety-nine isolates from military and civilian cases from different geographic locations and circulation periods were characterized by restriction enzyme analysis of viral DNA and select gene sequencing.

RESULTS:

All examined viruses were found to be identical and to belong to a new genome type designated "HAdV-14p1" (formerly known as "14a"). Comparative alignments of E1A, hexon, and fiber gene sequences with other subspecies B2 HAdVs suggest that HAdV-14p1, like the closely related HAdV-11a, arose from recombination among similar HAdV-11 and HAdV-14 ancestral strains. A deletion of 2 amino acids in the knob region of the fiber protein is the only identified unique characteristic of HAdV-14p1.

CONCLUSION:

The current geographic distribution of HAdV-14p1 involves at least 15 states in the Unites States. The role of the fiber mutations in the recent emergence of HAdV-14p1 ARD in North America warrants further study.

PMID:
20500088
DOI:
10.1086/653083
[Indexed for MEDLINE]

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