Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Immunol. 2010 Jun;10(6):403-14. doi: 10.1038/nri2780.

Cross-priming in health and disease.

Author information

  • 1Institutes of Molecular Medicine and Experimental Immunology, University Clinic of the Rheinische Friedrich-Wilhelms-Universit├Ąt, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. ckurts@web.de

Abstract

Cross-priming is an important mechanism to activate cytotoxic T lymphocytes (CTLs) for immune defence against viruses and tumours. Although it was discovered more than 25 years ago, we have only recently gained insight into the underlying cellular and molecular mechanisms, and we are just beginning to understand its physiological importance in health and disease. Here we summarize current concepts on the cross-talk between the immune cells involved in CTL cross-priming and on its role in antimicrobial and antitumour defence, as well as in immune-mediated diseases.

PMID:
20498667
DOI:
10.1038/nri2780
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center