Format

Send to

Choose Destination
Invest Radiol. 2010 Jul;45(7):445-52. doi: 10.1097/RLI.0b013e3181e21866.

Toward clinical X-ray phase-contrast CT: demonstration of enhanced soft-tissue contrast in human specimen.

Author information

1
Paul Scherrer Institut, Villigen PSI, Switzerland. tilman.donath@dectris.com

Abstract

OBJECTIVES:

X-ray computed tomography (CT) using phase contrast can provide images with greatly enhanced soft-tissue contrast in comparison to conventional attenuation-based CT. We report on the first scan of a human specimen recorded with a phase-contrast CT system based on an x-ray grating interferometer and a conventional x-ray tube source. Feasibility and potential applications of preclinical and clinical phase-contrast CT are discussed.

MATERIALS AND METHODS:

A hand of an infant was scanned ex vivo at 40 kVp tube voltage. The simultaneously recorded attenuation and phase-contrast CT images were quantitatively compared with each other, by introducing a specific Hounsfield unit for phase-contrast imaging.

RESULTS:

We observe significantly enhanced soft-tissue contrast in the phase images, when compared with the attenuation data. Particularly, tendons and ligaments appear with strongly increased contrast-to-noise ratio.

CONCLUSIONS:

Our results demonstrate the huge potential of phase-contrast CT for clinical investigations of human specimens and, potentially, of humans. Because the applied technique works efficiently with conventional x-ray tubes and detectors, it is suitable for the realization of preclinical and clinical phase-contrast CT systems.

PMID:
20498610
DOI:
10.1097/RLI.0b013e3181e21866
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center