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J Comput Assist Tomogr. 2010 May-Jun;34(3):372-6. doi: 10.1097/RCT.0b013e3181cefb89.

Breath-hold 1H-magnetic resonance spectroscopy for intrahepatic lipid quantification at 3 Tesla.

Author information

1
Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA. mbredella@partners.org

Abstract

OBJECTIVE:

To compare breath-hold 1H-magnetic resonance spectroscopy (1H-MRS) with respiratory-gated 1H-MRS and computed tomography (CT) for quantification of hepatic lipid content.

METHODS:

Twenty-three premenopausal women underwent breath-hold point-resolved single-voxel 1H-MRS of the liver followed by respiratory-gated 1H-MRS at 3 Tesla and CT slice through the liver. Interscan variability for 1H-MRS was assessed in 6 volunteers. Pearson correlation coefficients, Bland-Altman 95% limit of agreement, and concordance correlation coefficients were calculated.

RESULTS:

There was a strong correlation between breath-hold and respiratory-gated 1H-MRS (r = 0.94, P < 0.0001; concordance correlation coefficient, 0.75). Using Bland-Altman analysis, all but 2 data points were within the limits of agreement. Both 1H-MRS techniques had low interscan variability. There was an inverse correlation of both 1H-MRS techniques with CT attenuation values of the liver.

CONCLUSIONS:

Breath-hold 1H-MRS is a reliable method to measure hepatic lipid content at 3 Tesla. Breath-hold 1H-MRS of the liver provides data that closely correlates with that obtained from longer-duration respiratory-gated technique.

PMID:
20498538
PMCID:
PMC2877282
DOI:
10.1097/RCT.0b013e3181cefb89
[Indexed for MEDLINE]
Free PMC Article

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