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Antimicrob Agents Chemother. 2010 Aug;54(8):3475-7. doi: 10.1128/AAC.00464-10. Epub 2010 May 24.

Identification of the novel dfrK-carrying transposon Tn559 in a porcine methicillin-susceptible Staphylococcus aureus ST398 strain.

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1
Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut (FLI), Höltystr. 10, 31535 Neustadt-Mariensee, Germany.

Abstract

The trimethoprim resistance gene dfrK was found to be part of the novel Tn554-related transposon Tn559 integrated in the chromosomal radC gene of a porcine methicillin-susceptible Staphylococcus aureus ST398 strain. While Tn559 and Tn554 had similar arrangements of the transposase genes tnpA, tnpB, and tnpC, the Tn554-associated resistance genes erm(A) and spc were replaced by dfrK in Tn559. Circular forms of Tn559 were detected and suggest the functional activity of this transposon.

PMID:
20498309
PMCID:
PMC2916295
DOI:
10.1128/AAC.00464-10
[Indexed for MEDLINE]
Free PMC Article
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