Send to

Choose Destination
Cancer. 1991 Jul 1;68(1):195-7.

Natural history of vaginal intraepithelial neoplasia.

Author information

Department of Obstetrics and Gynecology, University Central Hospital, Helsinki, Finland.


The natural history of vaginal intraepithelial neoplasia (VAIN) was studied in 23 patients followed for at least 3 years with no treatment. The mean age of the patients was 41 years of age. A large proportion of the VAIN lesions (50%) were multifocal, and approximately one half of the lesions were associated with concomitant cervical or vulvar intraepithelial neoplasia. Progression to invasive vaginal carcinoma occurred in two (9%) cases, persistence of VAIN occurred in three (13%) cases, and regression of VAIN occurred in 18 (78%) cases. The risk for progression to invasive carcinoma emphasizes the significance of colposcopic examination of the vagina with directed biopsy specimens obtained from all lesions.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center