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Cancer. 1991 Jul 1;68(1):195-7.

Natural history of vaginal intraepithelial neoplasia.

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1
Department of Obstetrics and Gynecology, University Central Hospital, Helsinki, Finland.

Abstract

The natural history of vaginal intraepithelial neoplasia (VAIN) was studied in 23 patients followed for at least 3 years with no treatment. The mean age of the patients was 41 years of age. A large proportion of the VAIN lesions (50%) were multifocal, and approximately one half of the lesions were associated with concomitant cervical or vulvar intraepithelial neoplasia. Progression to invasive vaginal carcinoma occurred in two (9%) cases, persistence of VAIN occurred in three (13%) cases, and regression of VAIN occurred in 18 (78%) cases. The risk for progression to invasive carcinoma emphasizes the significance of colposcopic examination of the vagina with directed biopsy specimens obtained from all lesions.

PMID:
2049744
[Indexed for MEDLINE]
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