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Drug Class Review on HMG-CoA Reductase Inhibitors (Statins): Final Report [Internet].


Portland (OR): Oregon Health & Science University; 2006 Aug.
Drug Class Reviews.


In the United States, coronary heart disease (CHD) and cardiovascular disease (CVD) account for nearly 40% of all deaths each year. High levels of cholesterol, or hypercholesterolemia, are an important risk factor for CHD. The 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase inhibitors, also known as statins, are the most effective class of drugs for lowering serum low-density lipoprotein cholesterol (LDL-c) concentrations. The purpose of this review is to compare the efficacy and adverse effects of different statins.

Copyright & 2006, Oregon Health & Science University, Portland, Oregon.

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