Fractionation of the EtOH extract from the fruits of Broussonetia papyrifera led to the isolation of 15 phenolic compounds (1-15). Their structures were identified using spectroscopic methods. Among these compounds, 1 and 2 are new and 3-15 were isolated from this plant for the first time. Antioxidant activities of compounds 2-15 against H(2)O(2)-induced injury in SY5Y cells and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities were evaluated.