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Drug Class Review: Atypical Antipsychotic Drugs: Final Report Update 2 [Internet].


Portland, (OR): Oregon Health & Science University; 2008 Jun.
Drug Class Reviews.


"Atypical" antipsychotic agents are used to treat the symptoms of schizophrenia and bipolar disorder. The atypical antipsychotics interact with more neurotransmitter receptor types than conventional antipsychotics and vary from one another in receptor interaction selection and affinity. In general, atypical antipsychotics produce antipsychotic responses with fewer acute extrapyramidal side effects than "conventional" antipsychotic drugs. This review addresses the use of atypical antipsychotics to treat schizophrenia, bipolar disorder, behavioral and psychological symptoms of dementia (BPSD) in adults, and pervasive developmental disorders and disruptive behavior disorders in children. The purpose of this review is to help policy makers and clinicians make informed choices about the use of atypical antipsychotics by evaluating their comparative effectiveness and harms.

Copyright © 2008, Oregon Health & Science University, Portland, Oregon.

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