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Nat Rev Mol Cell Biol. 2010 Jun;11(6):414-26. doi: 10.1038/nrm2901.

Signalling ballet in space and time.

Author information

1
Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland. Boris.Kholodenko@ucd.ie

Abstract

Although we have amassed extensive catalogues of signalling network components, our understanding of the spatiotemporal control of emergent network structures has lagged behind. Dynamic behaviour is starting to be explored throughout the genome, but analysis of spatial behaviours is still confined to individual proteins. The challenge is to reveal how cells integrate temporal and spatial information to determine specific biological functions. Key findings are the discovery of molecular signalling machines such as Ras nanoclusters, spatial activity gradients and flexible network circuitries that involve transcriptional feedback. They reveal design principles of spatiotemporal organization that are crucial for network function and cell fate decisions.

PMID:
20495582
PMCID:
PMC2977972
DOI:
10.1038/nrm2901
[Indexed for MEDLINE]
Free PMC Article

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