Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Cancer. 2010 Jun;10(6):435-41. doi: 10.1038/nrc2841.

Implications and challenges of connexin connections to cancer.

Author information

1
Life Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia V6T-1Z3, Canada. Christian.naus@ubc.ca

Abstract

The idea that the gap junction family of proteins, connexins, are tumour suppressors has been widely supported through numerous cancer models. However, the paradigm that connexins and enhanced gap junctional intercellular communication is of universal benefit by restricting tumour growth has been challenged by more recent evidence that suggests a role for connexins in facilitating tumour progression and metastasis. Therefore, connexins might be better classified as conditional tumour suppressors that modulate cell proliferation, as well as adhesion and migration.

PMID:
20495577
DOI:
10.1038/nrc2841
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center