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Nat Struct Mol Biol. 2010 Jun;17(6):666-72. doi: 10.1038/nsmb.1842. Epub 2010 May 23.

Post-translational modifications in signal integration.

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1
Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University, Frankfurt, Germany.

Abstract

Post-translational modifications of proteins and the domains that recognize these modifications have central roles in creating a highly dynamic relay system that reads and responds to alterations in the cellular microenvironment. Here we review the common principles of post-translational modifications and their importance in signal integration underlying epidermal growth factor receptor signaling and endocytosis, DNA-damage responses and immunity.

PMID:
20495563
DOI:
10.1038/nsmb.1842
[Indexed for MEDLINE]
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