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Cell Cycle. 2010 Jun 1;9(11):2085-91. Epub 2010 Jun 1.

Dependence receptors: mechanisms of an announced death.

Author information

1
Apoptosis, Cancer and Development Laboratory, Equipe labellisée La Ligue, Université de Lyon, CNRS UMR5238, Lyon, France. chantal.thibert@ujf-grenoble.fr

Abstract

Dependence receptors form a family of functionally related receptors which are all able to induce two completely opposite intracellular signals depending on the availability of their ligand. Indeed, in its presence, they mediate a positive, classical signal transduction of survival, differentiation or migration but without it, they trigger a negative signal which leads to cell death. The molecular mechanisms involved in triggering cell death in the absence of ligand are starting to be unravelled: dependence receptors are recruited at well-defined domains at the plasma membrane, they trigger cell death through a monomeric form, they are cleaved by caspases and they recruit a caspase activating complex.

PMID:
20495383
PMCID:
PMC3325907
DOI:
10.4161/cc.9.11.11809
[Indexed for MEDLINE]
Free PMC Article

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