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Cell Immunol. 2010;264(1):32-41. doi: 10.1016/j.cellimm.2010.04.008. Epub 2010 May 5.

Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways.

Author information

1
Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030-1319, USA. cawu@nso1.uchc.edu

Abstract

IL-5 is a pleiotropic cytokine that promotes eosinophil differentiation and survival. While naïve bronchial epithelial cells (BEC) produce low levels of IL-5, the role of BEC-derived IL-5 in allergic airway inflammation is unknown. We now show that BEC, isolated from mice with OVA-induced allergic airway disease (AAD), produced elevated levels of IL-5 mRNA and protein as compared to BEC from naïve mice. To determine the contribution of BEC-derived IL-5 to effector responses in the airways, IL-5 deficient bone marrow chimeric mice were generated in which IL-5 expression was restricted to stromal (e.g. BEC) or hematopoietic cells. When subjected to AAD, IL-5 produced by BECs contributed to mucous metaplasia, airway eosinophilia, and OVA-specific IgA levels. Thus, IL-5 production by BEC can impact the microenvironment of the lung, modifying pathologic and protective immune responses in the airways.

PMID:
20494340
PMCID:
PMC2902557
DOI:
10.1016/j.cellimm.2010.04.008
[Indexed for MEDLINE]
Free PMC Article

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