Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochem Biophys Res Commun. 2010 May 21;396(1):105-10. doi: 10.1016/j.bbrc.2010.02.173.

Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis.

Author information

1
Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, 17177 Stockholm, Sweden. olof.radmark@ki.se

Abstract

5-Lipoxygenase (5LO) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid. LTs function in normal host defense, and have pathophysiological roles in chronic inflammatory diseases as asthma and atherosclerosis. Also, possible effects of 5LO products in relation to tumorigenesis have been described. Thus, insight regarding the biochemistry of 5LO is relevant for better understanding of normal physiology, and for development of therapy.

PMID:
20494120
DOI:
10.1016/j.bbrc.2010.02.173
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center