Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochem Biophys Res Commun. 2010 May 21;396(1):50-7. doi: 10.1016/j.bbrc.2010.02.141.

Induction and regulation of CD8+ cytolytic T cells in human tuberculosis and HIV infection.

Author information

1
Center for Infectious Medicine (CIM) F59, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden. susanna.brighenti@ki.se

Abstract

Tuberculosis and HIV continue to be the world-leading killers among infectious diseases, primarily affecting poor people in many developing countries. Despite differences in the immunopathogenesis of human infection with tuberculosis and HIV, experimental evidence from clinical studies and relevant animal models can be used to reflect on the cellular mechanisms responsible for an increased risk of active tuberculosis among HIV-infected individuals. In this review, we will discuss the molecular features and regulation of cytolytic T cells and how deficient cytolytic T cell responses contribute to the pathogenesis of TB and HIV infection as well as TB/HIV co-infection.

PMID:
20494110
DOI:
10.1016/j.bbrc.2010.02.141
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center