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Brain Res. 2010 Sep 10;1351:222-8. doi: 10.1016/j.brainres.2010.05.028. Epub 2010 May 21.

Reduction of intersectin1-s induced apoptosis of human glioblastoma cells.

Author information

1
Central Laboratory of Oncology Department, Tianjin Medical University Cancer Institute and Hospital, China.

Abstract

Malignant gliomas have a high proliferation ability and high tendency to invade diffusely into surrounding healthy brain tissues, thereby precluding their successful surgical removal. Intersectin1 (also called ITSN1) as a molecular linker in the central nervous system is well known as an important regulator of endocytosis and exocytosis. ITSN1 has two isoforms: ITSN1-l and ITSN1-s. In this study, we show that siRNA-mediated down regulation of ITSN1-s induced glioma cells apoptosis. In addition, we demonstrate the possible mechanisms by which ITSN1-s functions in glioma cells apoptosis. Our data demonstrate that several key proteins, including FAK, Akt, Bcl-2, BAD which are critical for cells apoptosis were probably involved in ITSN1-s signaling pathways. Our results indicate that ITSN1-s is an effecter in regulation of gliomas cells apoptosis, and identify that ITSN1-s may be a new potentially anti-apoptosis target for therapeutic of gliomas.

PMID:
20493827
DOI:
10.1016/j.brainres.2010.05.028
[Indexed for MEDLINE]

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