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Dev Cell. 2010 May 18;18(5):698-712. doi: 10.1016/j.devcel.2010.04.008.

Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development.

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1
Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA. fdc3@columbia.edu

Abstract

The two major components of the kidney, the collecting system and the nephron, have different developmental histories. The collecting system arises by the reiterated branching of a simple epithelial tube, while the nephron forms from a cloud of mesenchymal cells that coalesce into epithelial vesicles. Each develops into a morphologically complex and highly differentiated structure, and together they provide essential filtration and resorption functions. In this review, we will consider their embryological origin and the genes controlling their morphogenesis, patterning, and differentiation, with a focus on recent advances in several areas.

PMID:
20493806
PMCID:
PMC2883254
DOI:
10.1016/j.devcel.2010.04.008
[Indexed for MEDLINE]
Free PMC Article
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