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Dev Cell. 2010 May 18;18(5):694-6. doi: 10.1016/j.devcel.2010.04.009.

A master conductor for aggregate clearance by autophagy.

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Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA.


Autophagic adapters including p62/SQSTM1 recognize polyubiquitinated targets such as toxic protein aggregates. In a recent issue of Molecular Cell, Filimonenko et al. provide evidence that the phosphatidylinositol 3-phosphate (PI3P) binding protein, Alfy, interacts with p62, Atg5, and PI3P to coordinate target recognition with site-specific activation of autophagic components.

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