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Prog Urol. 2010 Mar;20 Suppl 1:S68-71. doi: 10.1016/S1166-7087(10)70031-2.

[Androgen deprivation therapy in locally advanced prostate cancer].

[Article in French]

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1
Service d'urologie Hôpital Nord, Chemin des Bourrely, Marseille cedex 20, France.

Abstract

In case of biochemical recurrence after radical prostatectomy, hormonal treatments are equally efficient. Early hormonal treatment after biochemical recurrence reduces specific mortality, local and metastatic progression. In locally advanced prostate cancer, adjuvant radiation therapy after biochemical recurrence reduces local and metastatic recurrence. Withdrawal of the steroid hormone should be the first maneuver after primary hormonal therapy failure. Second generation anti-androgens (abiraterone and MDV 3100) should be released soon. These new hormonal agents are in clinical trials and show promising activity in patients with CRPC.

PMID:
20493450
DOI:
10.1016/S1166-7087(10)70031-2
[Indexed for MEDLINE]
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