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Prog Biophys Mol Biol. 2010 Jun-Jul;102(2-3):122-8. doi: 10.1016/j.pbiomolbio.2010.05.001. Epub 2010 May 20.

Structure and function of SWI/SNF chromatin remodeling complexes and mechanistic implications for transcription.

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1
Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing 400044, China.

Abstract

ATP-dependent chromatin remodeling complexes are specialized protein machinery able to restructure the nucleosome to make its DNA accessible during transcription, replication and DNA repair. During the past few years structural biologists have defined the architecture and dynamics of some of these complexes using electron microscopy, shedding light on the mechanisms of action of these important assemblies. In this paper we review the existing structural information on the SWI/SNF family of the ATP-dependent chromatin remodeling complexes, and discuss their mechanistic implications.

PMID:
20493208
PMCID:
PMC2924208
DOI:
10.1016/j.pbiomolbio.2010.05.001
[Indexed for MEDLINE]
Free PMC Article
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