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Dev Biol. 2010 Aug 15;344(2):603-10. doi: 10.1016/j.ydbio.2010.05.018. Epub 2010 May 20.

Cell autonomous specification of temporal identity by Caenorhabditis elegans microRNA lin-4.

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1
Department of Genetics, Stanford University, Stanford, CA 94305, USA.

Abstract

MicroRNAs provide developing systems with substantial flexibility in posttranscriptional gene regulation. Despite advances made in understanding microRNA structure and function, the relationships between their site-of-synthesis and site-of-action ("autonomy" versus "non-autonomy") remain an open question. Given the well-defined role of microRNA lin-4 in a reproducible series of time-specific developmental switches, lin-4 is an excellent candidate for understanding whether microRNAs and the resulting heterochronic regulatory pathway have the potential to act cell autonomously. By monitoring temporal development and reporter activity in animals where lin-4 is modulated, we have demonstrated that lin-4 acts cell autonomously to specify temporal identity. This work (i) provides an example of cell autonomy in microRNA functions, and (ii) reveals a cell autonomous component of temporal regulation in C. elegans.

PMID:
20493184
PMCID:
PMC2914126
DOI:
10.1016/j.ydbio.2010.05.018
[Indexed for MEDLINE]
Free PMC Article
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