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Clin Infect Dis. 2010 Jul 1;51(1):58-65. doi: 10.1086/653116.

Getting under the skin: the immunopathogenesis of Streptococcus pyogenes deep tissue infections.

Author information

1
Karolinska Institutet, Center for Infectious Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Abstract

Streptococcus pyogenes can cause a variety of diseases in immunocompetent individuals, from pharyngotonsillitis to life-threatening invasive diseases, such as streptococcal toxic shock syndrome, and rapidly progressing deep-tissue infections, such as necrotizing fasciitis. Necrotizing fasciitis is often seen in combination with streptococcal toxic shock syndrome, which further increases morbidity and mortality. We review here the host-pathogen interactions in the tissue milieu and discuss the use of intravenous immunoglobulin as potential adjunctive therapy in these life-threatening infections.

PMID:
20491545
DOI:
10.1086/653116
[Indexed for MEDLINE]

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