Antimicrobial and cytotoxic activities of synthetically derived tambjamines C and E - J, BE-18591, and a related alkaloid from the marine bacterium Pseudoalteromonas tunicata

Chem Biodivers. 2010 May;7(5):1311-24. doi: 10.1002/cbdv.201000030.

Abstract

In the first comprehensive biological assessment of the tambjamine class of marine alkaloids, synthetically derived samples of compounds 1-9 have been subjected to evaluation as antimicrobial agents and screened for their cytotoxic effects on various human cancer cell lines. Most were strongly active against the fungus Malassezia furfur (>amphotericin B) and showed considerable, but non-selective, antiproliferative activity against both human cancer and normal cell lines. Tambjamines I and J (6 and 7, resp.) displayed significant apoptosis-inducing effects.

MeSH terms

  • Alkaloids / chemical synthesis
  • Alkaloids / chemistry*
  • Alkaloids / toxicity
  • Animals
  • Anti-Infective Agents / chemical synthesis*
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / toxicity
  • Cell Line, Tumor
  • Cytotoxins / chemical synthesis
  • Cytotoxins / chemistry*
  • Cytotoxins / toxicity
  • Drug Screening Assays, Antitumor
  • Erythrocytes / drug effects
  • Humans
  • Mice
  • Microbial Sensitivity Tests
  • Pseudoalteromonas / chemistry*
  • Pyrroles / chemical synthesis
  • Pyrroles / chemistry
  • Pyrroles / toxicity

Substances

  • Alkaloids
  • Anti-Infective Agents
  • Cytotoxins
  • Pyrroles
  • BE 18591