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AAPS J. 2010 Sep;12(3):437-42. doi: 10.1208/s12248-010-9199-8. Epub 2010 May 19.

Critical variables associated with nonbiodegradable osmotically controlled implants.

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1
DURECT Corporation, 2 Results Way, Cupertino, California 95014, USA. jeremy.wright@durect.com

Abstract

Osmotically controlled implants yield precise zero-order drug delivery kinetics and are utilized in a number of applications. The implants deliver drugs for extended periods (weeks to years) and exhibit good in vivo/in vitro correlation. This paper reviews critical variables associated with these implants, with a focus on release rate testing. The extended-duration kinetics can be problematic when attempting to test for >70% cumulative delivery. An innovative scheme based on the scientific principles of operation of the system is described to ensure > 70% delivery at the target rate and duration for the DUROS Viadur (leuprolide acetate) implant.

PMID:
20490735
PMCID:
PMC2895447
DOI:
10.1208/s12248-010-9199-8
[Indexed for MEDLINE]
Free PMC Article
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