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Org Biomol Chem. 2010 Jul 21;8(14):3118-27. doi: 10.1039/b926828f. Epub 2010 May 20.

The activation strain model of chemical reactivity.

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1
Department of Theoretical Chemistry and Amsterdam Center for Multiscale Modeling, VU University, De Boelelaan 1083, NL-1081 HV, Amsterdam, The Netherlands.

Abstract

Herein, we provide an account of the activation strain model of chemical reactivity and its recent applications. In this model, the potential energy surface DeltaE(zeta) along the reaction coordinate zeta is decomposed into the strain DeltaE(strain)(zeta) of the increasingly deformed reactants plus the interaction DeltaE(int)(zeta) between these deformed reactants, i.e., DeltaE(zeta) = DeltaE(strain)(zeta) + DeltaE(int)(zeta). The purpose of this fragment-based approach is to arrive at a qualitative understanding, based on accurate calculations, of the trends in activation barriers and transition-state geometries (e.g., early or late along the reaction coordinate) in terms of the reactants' properties. The usage of the activation strain model is illustrated by a number of concrete applications, by us and others, in the fields of catalysis and organic chemistry.

PMID:
20490400
DOI:
10.1039/b926828f
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