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QJM. 2010 Aug;103(8):625-6. doi: 10.1093/qjmed/hcq071. Epub 2010 May 20.

Multiple sclerosis and lung cancer: an unexpected inverse association.

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1
The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

Abstract

Multiple sclerosis is associated with a decreased risk of cancer. Smoking is a risk factor both for multiple sclerosis and lung cancer. We performed a meta-analysis on studies of cancer frequency in multiple sclerosis. Surprisingly, we found that the risk of lung cancer is reduced in multiple sclerosis [odds ratio 0.67 (95% confidence interval 0.59-0.76) P < 0.00001]. Since this does not appear to be secondary to altered smoking behaviour, we hypothesise that this may be secondary to altered immune surveillance.

PMID:
20488868
DOI:
10.1093/qjmed/hcq071
[Indexed for MEDLINE]
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