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Bioorg Med Chem Lett. 2010 Jun 15;20(12):3521-5. doi: 10.1016/j.bmcl.2010.04.138. Epub 2010 May 18.

Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes.

Author information

1
Shanghai Hengrui Pharmaceuticals Co., Ltd, Shanghai, China. tangpc@shhrp.com

Abstract

A series of novel bicyclo[3.3.0]octane derivatives have been synthesized and found to be dipeptidyl peptidase 4 (DPP-4) inhibitors. Compounds 10a and 10b demonstrate good efficacies in oral glucose tolerance tests.

PMID:
20488704
DOI:
10.1016/j.bmcl.2010.04.138
[Indexed for MEDLINE]

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