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Clin Chest Med. 2010 Jun;31(2):309-18. doi: 10.1016/j.ccm.2010.02.004.

Neurobiology of sleep.

Author information

1
Department of Medicine, California Pacific Medical Center, 2351 Clay Street, Suite 501, San Francisco, CA 94115, USA. lubs@sutterhealth.org

Abstract

The neurobiology of sleep is introduced in the context of interacting wake and sleep systems. Specifically, the transitions from wake to sleep and from non-rapid eye movement to rapid eye movement sleep are discussed based on the flip-flop switch hypothesis. Regulation of wake and sleep according to the opposing homeostatic and circadian systems are also presented.

PMID:
20488289
DOI:
10.1016/j.ccm.2010.02.004
[Indexed for MEDLINE]
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