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Dermatitis. 2010 May-Jun;21(3):148-53.

Vitamin E and allergic contact dermatitis.

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Center for Dermatology Research, Departments of Dermatology, Pathology, and Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1071, USA.


Reports of vitamin E-induced allergic contact dermatitis (ACD) and frequent use of vitamin-E derivatives (tocopherol, tocopheryl linoleate, tocopherol acetate, etc) in skin care products deserves further investigation into tolerability and suitability of vitamin E in skin care preparations. A PubMed search was conducted to review the prevalence of vitamin E-induced ACD. It revealed 931 cases of vitamin E-induced ACD mainly from one large study. There were no reported deaths and only three patients required hospitalization for treatment. It appears that vitamin E-induced ACD is an uncommon phenomenon; incidence is low despite its widespread use in skin care products. Given its antioxidant and photoprotective properties, vitamin E should remain an ingredient in skin care products.

[Indexed for MEDLINE]

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