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Biomarkers. 2010 Aug;15(5):400-9. doi: 10.3109/1354750X.2010.481365.

Tumour necrosis factor-alpha gene polymorphisms in asbestos-induced diseases.

Author information

1
Institut und Poliklinik für Arbeits- und Sozialmedizin, Justus-Liebig-Universität, Aulweg 129, D-35392 Giessen, Germany. Simone.Helmig@arbmed.med.uni-giessen.de

Abstract

BACKGROUND:

Tumour necrosis factor (TNF)-alpha influences the pathogenesis of lung fibrosis and carcinogenesis in normal cells. Polymorphisms of this gene have been suggested to be associated with susceptibility to lung diseases.

METHODS:

Association studies were performed in German subjects, using control subjects (n = 177), pulmonary fibrosis patients (n = 612) and bronchial carcinoma patients (n = 374).

RESULTS:

Compared with a healthy (control) group, a significant result could be obtained for the asbestosis (patient) group (crude odds ratio (OR(crude)) = 1.57; 95% confidence interval (CI) 1.05-2.36; p = 0.03), especially with severe lung asbestosis (OR(crude) = 4.15; 95% CI 1.06-16.16; p = 0.04). A significant association was revealed when comparing asbestosis patients (OR(crude) = 4.08; 95% CI 1.53-10.54; p = 0.004 and OR(adjusted) = 3.89; 95% CI 1.49-10.17; p = 0.006) with asbestos-induced lung cancer patients.

CONCLUSION:

The results confirm the hypothesis that TNF-alpha polymorphisms are associated with asbestos-induced fibrotic or malignant lung diseases in Germans.

PMID:
20486865
DOI:
10.3109/1354750X.2010.481365
[Indexed for MEDLINE]

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