Format

Send to

Choose Destination
Insect Sci. 2008 Feb;15(1):29-43.

Innate immunity in Drosophila: Pathogens and pathways.

Author information

1
Biology Department and the Graduate Center, The City College of the City University of New York, New York, USA.

Abstract

Following in the footsteps of traditional developmental genetics, research over the last 15 years has shown that innate immunity against bacteria and fungi is governed largely by two NF-kappaB signal transduction pathways, Toll and IMD. Antiviral immunity appears to stem from RNA interference, whereas resistance against parasitoids is conferred by Toll signaling. The identification of these post-transcriptional regulatory mechanisms and the annotation of most Drosophila immunity genes have derived from functional genomic studies using "model" pathogens, intact animals and cell lines. The D. melanogaster host has thus provided the core information that can be used to study responses to natural microbial and metazoan pathogens as they become identified, as well as to test ideas of selection and evolutionary change. These analyses are of general importance to understanding mechanisms of other insect host-pathogen interactions and determinants of variation in host resistance.

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center