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Phys Rev Lett. 2010 Apr 23;104(16):168104. Epub 2010 Apr 23.

Cell migration driven by cooperative substrate deformation patterns.

Author information

1
School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.

Abstract

Most eukaryotic cells sense and respond to the mechanical properties of their surroundings. This can strongly influence their collective behavior in embryonic development, tissue function, and wound healing. We use a deformable substrate to measure collective behavior in cell motion due to substrate mediated cell-cell interactions. We quantify spatial and temporal correlations in migration velocity and substrate deformation, and show that cooperative cell-driven patterns of substrate deformation mediate long-distance mechanical coupling between cells and control collective cell migration.

PMID:
20482085
PMCID:
PMC3947506
DOI:
10.1103/PhysRevLett.104.168104
[Indexed for MEDLINE]
Free PMC Article

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