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J Med Chem. 2010 Jun 24;53(12):4803-7. doi: 10.1021/jm100294b.

Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.

Author information

1
European Research Centre for Drug Discovery and Development, Universita di Siena, 53100 Siena, Italy.

Abstract

As a continuation of our efforts to develop innovative ligands for D(3), 5-HT(1A), and 5-HT(2A) receptors with low propensity to block hERG channels, we propose a series bishetero(homo)arylpiperazines 5a-m as novel and potent multifunctional ligands characterized by low occupancy at D(2) and 5-HT(2C) receptors.

PMID:
20481570
DOI:
10.1021/jm100294b
[Indexed for MEDLINE]

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