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Int J Mol Sci. 2010 Apr 26;11(4):1930-43. doi: 10.3390/ijms11041930.

Hub promiscuity in protein-protein interaction networks.

Author information

1
Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Japan. ashwini@hgc.jp

Erratum in

  • Int J Mol Sci. 2010;11(8):2791.

Abstract

Hubs are proteins with a large number of interactions in a protein-protein interaction network. They are the principal agents in the interaction network and affect its function and stability. Their specific recognition of many different protein partners is of great interest from the structural viewpoint. Over the last few years, the structural properties of hubs have been extensively studied. We review the currently known features that are particular to hubs, possibly affecting their binding ability. Specifically, we look at the levels of intrinsic disorder, surface charge and domain distribution in hubs, as compared to non-hubs, along with differences in their functional domains.

KEYWORDS:

hubs; interaction networks; promiscuous binding; protein-protein interactions

PMID:
20480050
PMCID:
PMC2871146
DOI:
10.3390/ijms11041930
[Indexed for MEDLINE]
Free PMC Article

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