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Int J Mol Sci. 2010 Apr 16;11(4):1808-24. doi: 10.3390/ijms11041808.

Intrinsically disordered proteins in bcl-2 regulated apoptosis.

Author information

1
Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.

Abstract

Intrinsic cell death is mediated by interaction between pro-apoptotic and pro-survival proteins of the B-cell lymphoma-2 (Bcl-2) family. Members of this family are either intrinsically disordered or contain intrinsically disordered regions/domains that are critical to their function. Alternate splicing and post-translational modifications can determine the extent of these disordered regions and are critical for regulating Bcl-2 proteins. Conformational plasticity and structural transitions characterize the interactions within the Bcl-2 family, with conserved sequence motifs on both binding partners required for their molecular recognition.

KEYWORDS:

BH3-only; Bcl-2; apoptosis; intrinsically disordered protein; protein structure

PMID:
20480043
PMCID:
PMC2871139
DOI:
10.3390/ijms11041808
[Indexed for MEDLINE]
Free PMC Article

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