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Mar Drugs. 2010 Apr 14;8(4):1213-62. doi: 10.3390/md8041213.

Conventional and unconventional antimicrobials from fish, marine invertebrates and micro-algae.

Author information

1
Scottish Oceans Institute, University of St Andrews, St Andrews, KY16 8LB, Scotland, UK. vjs1@st-andrews.ac.uk

Abstract

All eukaryotic organisms, single-celled or multi-cellular, produce a diverse array of natural anti-infective agents that, in addition to conventional antimicrobial peptides, also include proteins and other molecules often not regarded as part of the innate defences. Examples range from histones, fatty acids, and other structural components of cells to pigments and regulatory proteins. These probably represent very ancient defence factors that have been re-used in new ways during evolution. This review discusses the nature, biological role in host protection and potential biotechnological uses of some of these compounds, focusing on those from fish, marine invertebrates and marine micro-algae.

KEYWORDS:

amphipathicity; antimicrobial peptides; fatty acids; innate defence; pigments

PMID:
20479976
PMCID:
PMC2866484
DOI:
10.3390/md8041213
[Indexed for MEDLINE]
Free PMC Article

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