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Nat Rev Genet. 2010 Jun;11(6):405-14. doi: 10.1038/nrg2778.

The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts.

Author information

1
Department of Zoology, University of Oxford, Oxford OX1 3PS, UK. craig.maclean@zoo.ox.ac.uk

Abstract

Despite efforts from a range of disciplines, our ability to predict and combat the evolution of antibiotic resistance in pathogenic bacteria is limited. This is because resistance evolution involves a complex interplay between the specific drug, bacterial genetics and both natural and treatment ecology. Incorporating details of the molecular mechanisms of drug resistance and ecology into evolutionary models has proved useful in predicting the dynamics of resistance evolution. However, putting these models to practical use will require extensive collaboration between mathematicians, molecular biologists, evolutionary ecologists and clinicians.

PMID:
20479772
DOI:
10.1038/nrg2778
[Indexed for MEDLINE]

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