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J Gerontol B Psychol Sci Soc Sci. 2010 Jul;65(4):405-15. doi: 10.1093/geronb/gbq035. Epub 2010 May 17.

Human neuroscience and the aging mind: a new look at old problems.

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Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA.


In this article, marking the 65th anniversary of the Journal of Gerontology, we offer a broad-brush overview of the new synthesis between neuroscientific and psychological approaches to cognitive aging. We provide a selective review of brain imaging studies and their relevance to mechanisms of cognitive aging first identified primarily from behavioral measurements. We also examine some new key discoveries, including evidence favoring plasticity and compensation that have emerged specifically from using cognitive neuroscience methods to study healthy aging. We then summarize several recent neurocognitive theories of aging, including our own model-the Scaffolding Theory of Aging and Cognition. We close by discussing some newly emerging trends and future research trajectories for investigating the aging mind and brain.

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