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Cancer Cell. 2010 May 18;17(5):417-8. doi: 10.1016/j.ccr.2010.04.019.

A multipronged approach to the identification and study of an important oncogene in GBM.

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1
Intellectual and Developmental Disabilities Research Center and Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. harley@ucla.edu

Abstract

In this issue of Cancer Cell, Zheng et al. provide strong evidence that PLAGL2 serves as an oncogene in GBM. They demonstrate that PLAGL2 inhibits differentiation and promotes a persistent, self-renewing state, at least in part because of activation of Wnt signaling.

PMID:
20478522
DOI:
10.1016/j.ccr.2010.04.019
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