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Anim Genet. 2010 Dec;41(6):656-8. doi: 10.1111/j.1365-2052.2010.02056.x.

Melanism in guinea fowl (Numida meleagris) is associated with a deletion of Phenylalanine-256 in the MC1R gene.

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1
Departament de Biologia, Universitat de Girona, Girona, Catalonia, Spain. oriol.vidal@udg.cat

Abstract

We have characterized a deletion in the MC1R gene causing the loss of one amino acid (p.Phe256del), which is perfectly associated with melanism in guinea fowl (Numida meleagris). Co-segregation of the p.Phe256del with melanism was confirmed in 25 offspring born from a cross of two heterozygote birds; therefore we suggest that this mutation is responsible for the black phenotype. Interestingly, this is the first case of recessive melanism linked to MC1R.

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